RSS 1.0 | The Cape Peninsula University of Technology (CPUT) Electronic Theses and Dissertations (ETD) repository holds full-text theses and dissertations submitted for higher degrees at the University (including submissions from former Cape Technikon and Peninsula Technikon). |
Biomedical Technology - Masters Degrees
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Expression of circulating Microrna’s (Mirnas) in blood of mixed ancestry subjects with glucose intolerance
(Cape Peninsula University of Technology, 2018)Background: Early detection of individuals who are at risk of developing Glucose Intolerance would decrease the morbidity and mortality associated with this disease. MicroRNA is one of the most widely studied biomolecules ... -
Molecular characterisation of the multi-antibiotic resistant bacteria, Klebsiella Pneumoniae isolated from nosocomial infections
(Cape Peninsula University of Technology, 2017)Background: It is well established that Klebsiella pneumoniae (K. pneumoniae) is an opportunistic pathogenic organism that has been frequently identified as the cause of nosocomial and community acquired infections. ... -
Investigating the association between Leucocyte Telomere length and glucose intolerance
(Cape Peninsula University of Technology, 2017)Background: Telomeres are DNA-proteins situated at the ends of linear chromosomes, responsible for genome stabilization. A link has been previously described between leucocyte telomere length (LTL) and age-related inflammatory ... -
The antimicrobial and immunomodulatory effects of Cotyledon Orbiculata extracts
(Cape Peninsula University of Technology, 2018)The challenge of antimicrobial resistance has increased drastically over the years as more microorganisms are becoming resistant to the available conventional treatments. The burden of antimicrobial resistant infections ... -
Molecular characterisation of Mycobacterium Tuberculosis, clinical isolates obtained in the Khomas region, Windhoek, Namibia
(Cape Peninsula University of Technology, 2017)According to the Namibia National Tuberculosis Control Programme (NTCP) report of 2008, Namibia has one of the highest TB infection rates in the world with a case notification rate of 748/100,000. Rapid, specific and ... -
Markers of chronic immune activation and T-cell function in hyperglycaemia
(Cape Peninsula University of Technology, 2017)Type 2 diabetes mellitus (T2DM) is a chronic inflammatory condition characterised by hyperglycaemia; continuous activation of T-lymphocytes and immune dysregulation. Although the exact mechanisms of these phenomena are not ... -
DNA methylation : a risk factor for type 2 diabetes mellitus
(Cape Peninsula University of Technology, 2016)The early detection of individuals who are at risk of developing type 2 diabetes mellitus (T2DM) would decrease the morbidity and mortality associated with this disease. DNA methylation, the most widely studied epigenetic ... -
The role of Bcl-2 and bax protein expression on individual radiosensitivity
(Cape Peninsula University of Technology, 2017)Apoptosis is the dominant mechanism of cell death induced by radiation and is the key mechanism used to remove cells with significant DNA damage. Previous research investigated the feasibility of using the Leukocyte Apoptosis ... -
Validation of a recently proposed equation for the estimation of small, dense LDL particles from routine lipid measures in a population of mixed ancestry South Africans
(Cape Peninsula University of Technology, 2016)Cardiovascular diseases (CVD) are the leading cause of global mortality, of which over 75% occurred in low- and middle-income countries such as South Africa. The lipid profile, specifically decreased levels of high density ... -
An in vitro comparison of cellular destruction and metabolic effects occurring in stored, leuco-reduced and irradiated red blood cells
(Cape Peninsula University of Technology, 2016)Biochemical and haematological changes occur in red blood cellular products during the recommended storage period of 35 to 42 days at 1°C to 6°C. The restriction of the sodium/potassium pump at specified temperatures result ... -
Influence of temperature and pH on corrosion resistance of Ni–Cr and Co–Cr dental alloys on oral environment
(Cape Peninsula University of Technology, 2015)Dental alloys are widely used in direct contact with oral tissue. In recent years after the price of gold significantly increased, cheaper dental materials were generally considered in the market particularly dental ... -
Synthesis of Co-Cr-Mo/ fluorapatie nano-composite coating by pulsed laser depositionfor dental applications
(Cape Peninsula University of Technology, 2016)Metallic materials play an essential role in assisting with the repair or replacement of bone tissue that has become diseased or damaged. Metals are more suitable for load bearing applications compared to ceramics or ... -
Platelet function and activation in mixed ancestry subjects with hyperglycemia, from the Western Cape, South Africa
(Cape Peninsula University of Technology, 2016)Type 2 diabetes mellitus (T2DM) is a metabolic disorder which is characterised by insulin resistance, defective insulin secretion or both. The chronic state of hyperglycemia in diabetes is associated with microvascular ... -
Effects of red palm oil-supplementation on oxidative stress biomarkers in an experimental rat model
(Cape Peninsula University of Technology, 2012)Oxidative stress, in recent times appears to be a major underlying risk factor in the occurrence of various diseases such as cardiovascular disease (CVD) and ischemic heart disease (IHD). During oxidative stress, there ... -
Antioxidant status of South African beverages and its role on the chemical parameters in human blood
(Cape Peninsula University of Technology, 2009)In recent years antioxidants present in various beverages have attracted a great deal of research interest due to their potential benefits to human health. Epidemiological evidence shows an indirect relationship between ... -
An epidemiological study in the greater Durban area of gram negative bacilli resistant to aminoglycoside antibiotics
(Cape Technikon, 1998)This study was undertaken to investigate resistance to aminoglycoside antibiotics and the transfer of resistance in selected Gram negative bacilli in hospitals in the Greater Durban area in order to determine whether the ... -
'n Ondersoek na die vir bepaling van serum- en toepassing van essaieringstelle verwysingswaardes vir vitamien rooiselfolaat by verskillende etniese groepe
(Cape Technikon, 1992)As early as 1822 it was discovered that treating a patient, who had a macrocytic anaemia, with a diet containing liver, a rich source of folic acid (folacin), brought about an excellent haematological response. extract, ... -
The effect of steroid hormones on the size of myometrial cells : a morphometric study
(Cape Technikon, 1997)The aims of this study were to measure: 1. Myometrial cells of menopausal uteri to establish whether they atrophy after the menopause. 2. Myometrial cells at different phases of the menstrual cycle to investigate ... -
Mitochondrial DNA heteroplasmy in radiation induced myelodysplasia and leukaemia
(Cape Technikon, 1996)Haematological defects observed in clonal deletions of mtDNA and the inhibition of mitochondrial function by benzene and chloramphenicol, suggest a role for mtDNA in the pathogenesis of radiation - induced preleukaemia ... -
The effect of Rooibos on trace elements absorption and biochemical parameters : a murine model
(Cape Peninsula University of Technology, 2014)Over the past few decades, it has been shown that various critical diseases including heart disease, cancer, and diabetes associated with free radical generation and low endogenous antioxidant capacity, lead to oxidative ...
