 | The Cape Peninsula University of Technology (CPUT) Electronic Theses and Dissertations (ETD) repository holds full-text theses and dissertations submitted for higher degrees at the University (including submissions from former Cape Technikon and Peninsula Technikon). |
Browsing Biomedical Technology - Doctoral Degree by Title
Now showing items 1-20 of 20
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Anti-p53 and c-erbB2 as prognostic markers in South African breast cancer patients
(Cape Technikon, 2000)The diagnosis of breast cancer is not possible using currently available serological detection of cancer markers as these lack adequate sensitivity or specificity. This study investigates the prevalence and significance ... -
Antidiabetic and profertility mechanisms of aqueous extract of Basella alba in male Wistar rats
(Cape Peninsula University of Technology, 2017)The use of medicinal plants in the management of various health problems date back to the ancient times. However, only in recent years, researchers are starting to focus on the use of natural plant products as alternative ... -
Biocatalytic production of new antioxidant compounds and the characterization of their antioxidant effects
(Cape Peninsula University of Technology, 2012)Antioxidants are an important class of compounds that quench reactive free radical intermediates formed during oxidative reactions. They prevent oxidative reactions in food and protect biological tissues against oxidative ... -
Cardiovascular disease risk profile of the South-African mixed ancestry population with high incidence of diabetes mellitus: baseline and three year follow-up
(Cape Peninsula University of Technology, 2013)Introduction: Cardiovascular diseases (CVD) have become the leading cause of morbidity and mortality amongst the global population. Originally thought to be a health burden of high income countries, the prevalence is rapidly ... -
Effect of rooibos and red palm oil supplementation, alone or in combination, on cardiac function after exposure to hypertension and inflammation in an ischaemial/reperfusion injury model
(Cape Peninsula University of Technology, 2013)Cardiovascular disease (CVD) is without a doubt one of the most challenging health issues of our time and accounts for the highest number of deaths in both developed and developing countries. Despite the huge strides that ... -
Effects of dietary red palm oil supplementation on myocardial infarct size in normal and hypercholesterolaemic rats: the role of matrix metalloproteinase 2, glutathione peroxidase transcription and extracellular signal regulated kinase phosphorylation
(Cape Peninsula University of Technology, 2010)Cardiovascular disease remains one of the leading causes of death globally. Many pharmacotherapeutic strategies are constantly being developed in order to effectively reduce the prevalence, as well as the morbidity and ... -
Effects of exposure to continuous low doses of ionizing radiation
(Cape Technikon, 2001)Ionising radiation has the ability to induce, inter alia, DNA damage and is well established as a causative agent of carcinogenesis and mutagenesis. The effects of high doses of short duration have been well documented, ... -
Effects of kolaviron–a Garcinia kola biflavonoid on biochemical and histological parameters in streptozotocin - induced diabetes and diabetic complications (nephrotoxicity and hepatotoxicity) in male Wistar rats
(Cape Peninsula University of Technology, 2014)Diabetes mellitus (DM) results in severe metabolic imbalances and pathological changes in many tissues. Chronic inflammation and oxidative stress have been implicated in the pathophysiology of diabetes mellitus. Garcinia ... -
Exploitation of the potential of a novel bacterial peroxidase for the development of a new biocatalytic process
(Cape Peninsula University of Technology, 2014)Peroxidases are ubiquitous catalysts that oxidise a wide variety of organic and inorganic compounds employing peroxide as the electron acceptor. They are an important class of oxidative enzymes which are found in nature, ... -
Homocystinuria and hyperhomocysteinaemia in the Western Cape
(Cape Technikon, 2002)Research into the role of homocyst(e)ine in cellular functions was stimulated by homocystinuria, a severe autosomal recessive disorder caused by, in the classic case, deficiency of cystathionine β-synthase. Patients with ... -
Improved modulation of the endogenous antioxidant system and inflammatory responses in male wistar rats by rooibos (Aspalathus linearis) and red palm oil (Elaeis guineensis)
(Cape Peninsula University of Technology, 2012)Oxidative stress and chronic (low-grade) inflammation are inseparably interconnected and both have been implicated in the aetiology of many disease states. The use of plant extracts for disease prevention and therapeutic ... -
Influence of two plant products (red palm oil and rooibos) on streptozotocin-induced hyperglycaemia and its implications on antioxidant status and other biochemical parameters in an animal model
(Cape Peninsula University of Technology, 2012)Diabetes mellitus is a major health problem not only in urban, but also in the rural areas and is diagnosed by the presence of high glucose levels in the blood. Oxidative stress is known to be actively involved in the onset ... -
Investigation into the bacterial pollution in three Western Cape rivers, South Africa and the application of bioremediation strategies as clean-up technology
(Cape Peninsula University of Technology, 2008)The quality of South Africa’s water sources is fast deteriorating due to an influx of pollutants from industrial and agricultural areas. In addition, urbanisation has led to the establishment of informal settlements along ... -
Investigation into the metal contamination of three rivers in the Western Cape and the subsequent application of a bioreactor system as remediation technology
(Cape Peninsula University of Technology, 2008)River systems can become contaminated with micro-organisms and metals and the routine monitoring of these rivers is essential to control the occurrence of these contaminants in water bodies. This study was aimed at ... -
Membrane fluidity and fatty acids in multiple sclerosis patients
(Cape Peninsula University of Technology, 2009)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which leads to neuronal demyelination, and eventually to oligodendrocyte and axon loss, with subsequent lesion formation. The ... -
Modulation of the redox status, phase 2 drug metabolizing enzymes and fumonisin-induced cancer promotion in rat liver by selected Southern African medicinal plants
(Cape Peninsula University of Technology, 2014)According to the World Health Organization, cancer is the leading cause of death in the developed world, while it is the second leading cause of death in the developing world. In particular, liver cancer is the fifth most ... -
Modulatory effects of Moringa oleifera extracts on Streptozotocin-induced diabetes in male Wistar rats
(Cape Peninsula University of Technology, 2017)Diabetes mellitus (DM) is characterized by deficiency in insulin resulting in hyperglycaemia with metabolic alterations in carbohydrate, lipid and protein. DM has been associated with increased formation of reactive oxygen ... -
The role of blood groups in preventing or enhancing HIV infection in Botswana
(Cape Peninsula University of Technology, 2019)Knowledge of population vulnerabilities to infectious diseases is key in managing many public health problems and for mapping appropriate strategies for prevention or intervention. A number of genes associated with resistance ... -
The application of nuclear microprobe analysis in materials science
(Peninsula Technikon, 2003)The impetus for the refinement and renewal of daily-used products has spurred international interest in investigating the small in homogeneities that might exist in these products. This interest has become an important ... -
The impact of organic hydroperoxides and a red palm oil supplemented diet on spermatogenesis, sperm function and sperm apoptosis
(Cape Peninsula University of Technology, 2009)Many environmental, physiological, and genetic factors have been shown to impair sperm function through oxidative damage. Oxidative stress (OS) arises as a consequence of excessive reactive oxygen species (ROS) production ...
