dspaceThe Cape Peninsula University of Technology (CPUT) Electronic Theses and Dissertations (ETD) repository holds full-text theses and dissertations submitted for higher degrees at the University (including submissions from former Cape Technikon and Peninsula Technikon).

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dc.contributor.advisorHugo, V.I., Prof
dc.contributor.authorWicht, Merril Margaret
dc.date.accessioned2014-07-25T07:28:23Z
dc.date.accessioned2016-01-26T09:05:20Z
dc.date.available2014-07-25T07:28:23Z
dc.date.available2016-01-26T09:05:20Z
dc.date.issued2007
dc.identifier.urihttp://hdl.handle.net/20.500.11838/732
dc.descriptionA thesis submitted to the Cape Peninsula University of Technology in fulfilment of the requirements for the MASTERS DEGREE IN TECHNOLOGY (CHEMISTRY) Department of Chemistry January 2007en_US
dc.description.abstractAn increasing number of natural products possessing the oleanolic acid moiety have been shown to demonstrate a wide spectrum of biological activity. This thesis deals with the extraction and isolation of oleanolic acid from Syzigium aromaticum and the examination of its stereochemistry and crystal structure by X-ray diffraction. The synthetic routes used for converting functional groups on the oleanolic acid molecule to afford derivatives are described in Chapter 5. Oleanolic acid and its derivatives were evaluated for antimicrobial activity. Three different procedures viz. Kirby-Bauer, Broth dilution and Tetrazolium salt chemosensitivity were used. Acceptable results were obtained from the last method and these were used to arrive at conclusions regarding this study.en_US
dc.language.isoenen_US
dc.publisherCape Peninsula University of Technologyen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/
dc.subjectOleanolic acid -- Testingen_US
dc.subjectAnti-infective agentsen_US
dc.subjectMTechen_US
dc.titleOleanic acid: its isolation and derivatisation to potential antimicrobial compoundsen_US
dc.typeThesisen_US


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