Please use this identifier to cite or link to this item: https://etd.cput.ac.za/handle/20.500.11838/730
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dc.contributor.advisorJacobs, Ayesha, Profen_US
dc.contributor.advisorNassimbeni, Lungi R., Profen_US
dc.contributor.authorSebogisi, Baganetsi Karaboen_US
dc.date.accessioned2014-03-06T08:58:08Z-
dc.date.accessioned2016-01-26T09:05:17Z-
dc.date.available2014-03-06T08:58:08Z-
dc.date.available2016-01-26T09:05:17Z-
dc.date.issued2012-
dc.identifier.urihttp://hdl.handle.net/20.500.11838/730-
dc.descriptionThesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2012en_US
dc.description.abstractChirality is very important to the pharmaceutical industry as enantiomers have the same macroproperties except for their optical and pharmacological activity. Industrial research has thus focused to find the most effective resolution technique. However, our aim was to obtain more information regarding the discrimination process. In this project the structures of the hydrates of di-quininium L-malate, (2QUIN+)(L-MA2-)•2H2O and the di-quininium D-malate, (2QUIN+)(D-MA2-)•2H2O have been investigated. (-)-Quinine (QUIN) did not show selectivity between the D and L malic acid and the structure of (2QUIN+)(DL-MA2-)•2H2O was obtained. Effect of solvents was demonstrated in the study and the structure of (QUIN+)(D-MA-)•H2O) was reported. The relationship between C-O bonds of the carboxylate and carboxylic moieties and ÄpKa was explored in salt and co-crystal formation. Kinetics of absorption was conducted for the reaction of (+)-deoxycholic acid (DCA) with n-propylamine and DCA with racemic sec-butylamine. The rate constants of the reactions were determined. Kinetics of desolvation was performed on the powder samples of mixtures of DCA and sec-butylamine and DCA with di-n-butylamine. Non-isothermal methods were used where a series of TG analyses was carried out at different heating rates (2, 4, 10, 32 K min-1). The structures of DCA with n-propylamine and di-n-butylamine were elucidated. The selectivity of DCA was investigated. The host compound was found to be able to successfully resolve racemic sec-butylamine (2-BUAM) and 2-amino-3-methylbutane (MeBUAM). The structures of DCA with enantiomers of these guests are reported in the study. The structures of R-BUAM and S-BUAM were solved in different space groups while R-MeBUAM and S-MeBUAM crystallized in the same space group.en_US
dc.language.isoenen_US
dc.publisherCape Peninsula University of Technologyen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.subjectChiralityen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectEnantiomers -- Separationen_US
dc.subjectEnantiomers -- Biotechnologyen_US
dc.subjectQuinineen_US
dc.subjectDeoxycholic aciden_US
dc.subjectDeoxycholic aciden_US
dc.subjectDissertations, Academicen_US
dc.subjectMTechen_US
dc.subjectTheses, dissertations, etc.en_US
dc.titleSeparation of racemates via host-guest chemistryen_US
dc.typeThesisen_US
Appears in Collections:Chemistry - Masters Degrees
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