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Multicomponent crystals of vanillic acid
Author(s)
Tshahwa, Célestine Nyingika
Date Issued
2025
Type
Thesis
Publisher
Cape Peninsula University of Technology
Abstract
Vanillic acid (VA) was used to form multicomponent crystals with 4,4-bipyridine (4,4-BP), 4- dimethylaminopyridine (4DMAP), 2-amino-5-methylpyridine (A25MP), 2-amino-6- methylpyridine (A26MP), 2-aminopyridine (A2MP) and 4-aminopyridine (A4MP). Six compounds were prepared using the slow evaporation technique comprising one cocrystal, three salts and two salt hydrates. The compounds were characterised using FTIR spectroscopy, thermal analysis and powder X-ray diffraction. Crystal structures were determined using single crystal X-ray diffraction. Some compounds were successfully prepared using the grinding procedure, while others were only partially converted. Thermogravimetry was used for the salt hydrates to obtain the percentage water contained in the crystal structures. Supramolecular interactions in the obtained crystal structures of the cocrystal, salts and salt hydrates are dominated by hydrogen bonding (O-H···O and O-H···N), whereas π-π stacking and C-H··· π interactions played a minor role in the packing arrangements of the new solid forms
Additional information
Thesis (Master of Applied Science: Chemistry)--Cape Peninsula University of Technology, 2025
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Celestine_Tshahwa_219124094.pdf
Size
2.32 MB
Format
Adobe PDF
Checksum
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