Loading...
Oleanic acid: its isolation and derivatisation to potential antimicrobial compounds
Author(s)
Wicht, Merril Margaret
Date Issued
2007
Type
Thesis
Publisher
Cape Peninsula University of Technology
Abstract
An increasing number of natural products possessing the oleanolic acid moiety
have been shown to demonstrate a wide spectrum of biological activity.
This thesis deals with the extraction and isolation of oleanolic acid from
Syzigium aromaticum and the examination of its stereochemistry and crystal
structure by X-ray diffraction.
The synthetic routes used for converting functional groups on the oleanolic acid
molecule to afford derivatives are described in Chapter 5.
Oleanolic acid and its derivatives were evaluated for antimicrobial activity.
Three different procedures viz. Kirby-Bauer, Broth dilution and Tetrazolium salt
chemosensitivity were used. Acceptable results were obtained from the last
method and these were used to arrive at conclusions regarding this study.
have been shown to demonstrate a wide spectrum of biological activity.
This thesis deals with the extraction and isolation of oleanolic acid from
Syzigium aromaticum and the examination of its stereochemistry and crystal
structure by X-ray diffraction.
The synthetic routes used for converting functional groups on the oleanolic acid
molecule to afford derivatives are described in Chapter 5.
Oleanolic acid and its derivatives were evaluated for antimicrobial activity.
Three different procedures viz. Kirby-Bauer, Broth dilution and Tetrazolium salt
chemosensitivity were used. Acceptable results were obtained from the last
method and these were used to arrive at conclusions regarding this study.
Additional information
Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2007
File(s)![Thumbnail Image]()
Loading...
Name
202088324_Wicht_MM_2007.pdf
Description
Thesis
Size
9.41 MB
Format
Adobe PDF
Checksum
(MD5):0d3f201ce21c0bd3ea6e3309b6a7ec4e