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Effect of smoking and waist circumference on biochemical markers of oxidative stress in subjects with IGT and newly diagnosed diabetics from Bellville South, Western Cape, South Africa
Author(s)
Tjaronda, Timothy Ngatangwe
Date Issued
2011
Type
Thesis
Publisher
Cape Peninsula University of Technology
Abstract
Studies have shown that oxidative stress (OS) is a major pathological risk factor in various
diseases, including type 2 diabetes mellitus (T2DM). Hyperglycemia independently is a
generator of free radicals, hence increases the level of OS in T2DM subjects. The oxidation
of LDL is suggested to play a significant role in the pathogenesis of macrovascular
complications observed in diabetic patients. In subjects with hyperglycemia or
normoglycemia we investigated the relationship between MDA-protein adducts, HNE-protein
adducts and auto-antibodies against oxLDL, and cardiovascular profile as measured by hs-
CRP.
From an epidemiological study that screened a high risk urban population for diabetes using
oral glucose tolerance test, 98 hyperglycaemie and 79 normoglycaemic individuals were
selected for this study. Enzyme linked immuno-sorbent-assay methods were used to
determine the levels of serum MDA-protein adducts, HNE-protein adducts or auto-antibodies
against oxLDL. High sensitive CRP was measured by nephelometry.
diseases, including type 2 diabetes mellitus (T2DM). Hyperglycemia independently is a
generator of free radicals, hence increases the level of OS in T2DM subjects. The oxidation
of LDL is suggested to play a significant role in the pathogenesis of macrovascular
complications observed in diabetic patients. In subjects with hyperglycemia or
normoglycemia we investigated the relationship between MDA-protein adducts, HNE-protein
adducts and auto-antibodies against oxLDL, and cardiovascular profile as measured by hs-
CRP.
From an epidemiological study that screened a high risk urban population for diabetes using
oral glucose tolerance test, 98 hyperglycaemie and 79 normoglycaemic individuals were
selected for this study. Enzyme linked immuno-sorbent-assay methods were used to
determine the levels of serum MDA-protein adducts, HNE-protein adducts or auto-antibodies
against oxLDL. High sensitive CRP was measured by nephelometry.
Additional information
Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2011.
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20124297_Tjaronda_TN_Mtech_Bio_Tech_HWSci_2011_20124297.pdf
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Thesis
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