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The antimicrobial susceptibility and gene-based resistance of Streptococcus Agalactiae (group B Streptococcus) in pregnant women in Windhoek (Khomas region), Namibia
Author(s)
Engelbrecht, Fredrika
Date Issued
2015
Type
Thesis
Publisher
Cape Peninsula University of Technology
Abstract
BACKGROUND AND OBJECTIVES: Group B Streptococci (GBS) can asymptomatically colonise the vagina and rectum of women. Studies have shown that this bacterium is the leading cause of septicemia, meningitis and pneumonia in neonates. In Namibia no known studies have investigated GBS colonisation and the antibiotic resistance profile of GBS isolates in pregnant women. This study accessed the GBS colonisation rate amongst the pregnant women who attended the Windhoek Central Hospital Antenatal Clinic (Khomas region), in Namibia for a period of 13 months. Furthermore, using the VITEK 2 system, the GBS isolates were tested against the following antimicrobial substances; benzylpenicillin, ampicillin, clindamycin, erythromycin, tetracycline, vancomycin, cefotaxime, ceftriaxone, linezolid and trimethoprim/sulfamethoxazole. Penicillin G is the drug of choice in the majority of studies, and seems to be the most effective drug for intrapartum antibiotic prophylaxis (IAP). All the GBS isolates found in this study were also analysed for the presence of selected genes known to be associated with resistance to key antibiotics using specific primers within a polymerase chain reaction (PCR).
Additional information
Thesis (MTech (Biomedical Sciences))--Cape Peninsula University of Technology, 2015.
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Name
200668919_Engelbrecht_F_MTech_Bio_Med_HWSci_2016.pdf
Description
Thesis
Size
1.77 MB
Format
Adobe PDF
Checksum
(MD5):af68b16d9e0003c7666f958b8b7ddd67