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Echocardiography for early detection of heart disease in high risk diabetic patients
Author(s)
Hartnick, Maria Diana
Date Issued
2015
Type
Thesis
Publisher
Cape Peninsula University of Technology
Abstract
Introduction: Diabetes mellitus is a chronic disease with a significant impact on
personal lifestyle and wellbeing. It is associated with a high prevalence of myocardial
disease, the early detection of which is important for prevention of disease
progression. Although echocardiography is recognised as a leading cardiovascular
imaging modality, there has been limited work on its role in the early detection of
diabetes-related myocardial dysfunction. The aim of this study was therefore to
evaluate the role of echocardiography in the early detection of diabetes-related
myocardial disease, in a population with a high prevalence of type 2 diabetes
mellitus. Methodology: A single sonographer, blinded to individual biochemical
markers conducted detailed echocardiographic examinations on 407 participants
from a Cape Town community with a high prevalence of diabetes mellitus.
Participants were subsequently stratified by biochemical status, as normoglyceamia
or hyperglycaemia. The echocardiographic features of the two groups were
compared using the Pearson chi-squared and Mann-Whitney U tests. Findings:
Hyperglycaemia was associated with left atrium (LA) enlargement (p ˂ 0.0014),
aortic enlargement (p ˂ 0.0067) and inter-ventricular septal (IVS) thickening (p ˂
0.0001). Conclusion: The findings suggest that echocardiography can be a useful
screening tool for myocardial dysfunction in Type 2 diabetes mellitus.
personal lifestyle and wellbeing. It is associated with a high prevalence of myocardial
disease, the early detection of which is important for prevention of disease
progression. Although echocardiography is recognised as a leading cardiovascular
imaging modality, there has been limited work on its role in the early detection of
diabetes-related myocardial dysfunction. The aim of this study was therefore to
evaluate the role of echocardiography in the early detection of diabetes-related
myocardial disease, in a population with a high prevalence of type 2 diabetes
mellitus. Methodology: A single sonographer, blinded to individual biochemical
markers conducted detailed echocardiographic examinations on 407 participants
from a Cape Town community with a high prevalence of diabetes mellitus.
Participants were subsequently stratified by biochemical status, as normoglyceamia
or hyperglycaemia. The echocardiographic features of the two groups were
compared using the Pearson chi-squared and Mann-Whitney U tests. Findings:
Hyperglycaemia was associated with left atrium (LA) enlargement (p ˂ 0.0014),
aortic enlargement (p ˂ 0.0067) and inter-ventricular septal (IVS) thickening (p ˂
0.0001). Conclusion: The findings suggest that echocardiography can be a useful
screening tool for myocardial dysfunction in Type 2 diabetes mellitus.
Additional information
Thesis (MTech (Radiography))--Cape Peninsula University of Technology, 2015
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